Interventions: what is known in dogs

Every compound the NIA Interventions Testing Program has tested for lifespan in mice (54 compounds in DrugAge), plus veterinary comparators. For each: DrugAge experiments by species, dog-equivalent doses by the FDA Km method, the canine aging literature, FDA FOI summaries, and the gaps.

Of the 54 ITP compounds, 0 have a dog lifespan experiment in DrugAge and 20 are mentioned anywhere in the 3,564-record canine aging corpus.

CompoundITP rowsDog lifespan rowsCanine papers mentioning itFDA FOI summaries
(R/S)-1,3-butanediol2000
16-alpha-hydroxyestradiol2000
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride2000
17‐alpha‐estradiol6000
2,4-dinitrophenol2000
2-(2-hydroxyphenyl)benzothiazole2000
4-hydroxyphenyl-N-tert-butylnitrone2000
4-phenylbutyrate2000
Acarbose10000
Alpha-ketoglutarate2010
Aspirin6020
Astaxanthin2060
Beta-guanidinopropionic acid2000
Caffeic acid phenethylester4000
Canagliflozin6020
Candesartan cilexetil2000
Captopril2000
Curcumin2020
Dimethyl fumarate4000
Enalapril2010
Fisetin4000
Fish oil40130
Geranylgeranylacetone2010
Glycine20120
Green tea extract2010
Hydralazine4000
INT-767d (FXR/TGR5 agonist)2000
Inulin2050
Leucine20110
MIF098 (CD74 antagonist)2000
Meclizine2000
Medium-chain triglyceride oil2000
Metformin2080
Methylene blue2010
Minocycline2000
MitoQ2020
Mycophenolic acid2020
Nebivolol2000
Nicotinamide riboside2000
Nitroflurbiprofen2000
Nordihydroguaiaretic acid6000
Oxaloacetate2020
PB125 (carnosol, withaferin A and luteolin)2000
Protandim2000
Rapamycin1601520
Resveratrol6030
SG1002 (hydrogen sulfide donor)4000
Simvastatin4000
Sodium thiosulfate2000
Sulindac2000
Syringaresinol2000
TM5441 (PAI-1 inhibitor)2000
Ursodeoxycholic acid2000
Ursolic acid2010
Selegiline01192
Carprofen00111