Ursolic acid in dogs: the evidence
What the aging-research databases and the canine literature hold for Ursolic acid (names searched: Ursolic acid, Ursolic--acid). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
5 experiments recorded, by species: Caenorhabditis elegans 2, Mus musculus 2, Drosophila melanogaster 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 2000 ppm food | 10 months | until death | Female | 0 | NS | -1 | NS | PMID 30688027 |
| Mus musculus | UM-HET3 | 2000 ppm food | 10 months | until death | Male | 6 | NS | 0 | NS | PMID 30688027 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 25 µM | Unknown | 32.48 | S | NA | PMID 27773812 | |||
| Caenorhabditis elegans | N2 | 25 µM | Unknown | 31.3 | S | NA | PMID 28673026 | |||
| Drosophila melanogaster | w1118 | 50 µmol/L | Unknown | 12.78 | S | NA | PMID 30496629 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
1 corpus records mention this compound.
Records matching randomized or placebo-controlled trial vocabulary
- Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy. (Animals : an open access journal from MDPI, 2024). PMID 38254356
…a novel ursolic acid dietary supplement for dogs and confirmed its safety and tolerability in dogs. We then conducted a randomized, placebo-controlled, proof…
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Ursolic acid") in dog-geroscience-mcp.