Simvastatin in dogs: the evidence
What the aging-research databases and the canine literature hold for Simvastatin (names searched: Simvastatin). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
8 experiments recorded, by species: Mus musculus 4, Caenorhabditis elegans 3, Drosophila melanogaster 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 120 ppm food (20 ppm/day bodyweight) | 10 months | until death | Female | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 120 ppm food (20 ppm/day bodyweight) | 10 months | until death | Male | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 12 ppm food (2 ppm/day bodyweight) | 10 months | until death | Female | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 12 ppm food (2 ppm/day bodyweight) | 10 months | until death | Male | 0 | NS | 0 | NS | PMID 20974732 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 50 µM | Unknown | 13.2 | S | NA | PMID 32010481 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 12.9 | S | NA | PMID 32010481 | |||
| Caenorhabditis elegans | N2 | 25 µM | Unknown | 2.5 | NS | NA | PMID 32010481 | |||
| Drosophila melanogaster | 240 µM | Unknown | 25 | S | NA | PMID 22737247 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Simvastatin") in dog-geroscience-mcp.