Methylene blue in dogs: the evidence
What the aging-research databases and the canine literature hold for Methylene blue (names searched: Methylene blue, Methylene-blue). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
6 experiments recorded, by species: Drosophila melanogaster 4, Mus musculus 2.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 27 ppm food | 4 months | until death | Female | 1 | NS | 6 | S | PMID 24245565 |
| Mus musculus | UM-HET3 | 27 ppm food | 4 months | until death | Male | -2 | NS | -5 | NS | PMID 24245565 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Oregon-R | 0.001 mM | Male | 0 | NS | NA | PMID 8350657 | |||
| Drosophila melanogaster | Oregon-R | 0.01 mM | Male | 8 | S | NA | PMID 8350657 | |||
| Drosophila melanogaster | Oregon-R | 0.1 mM | Male | -2 | NS | NA | PMID 8350657 | |||
| Drosophila melanogaster | Oregon-R | 1 mM | Male | -49 | S | NA | PMID 8350657 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
1 corpus records mention this compound.
Top hits in the core tier
- Electron probe microanalysis оf experimentally stimulated osteoarthrosis in dogs. (World journal of orthopedics, 2017). PMID 28979851
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Methylene blue") in dog-geroscience-mcp.