2,4-dinitrophenol in dogs: the evidence
What the aging-research databases and the canine literature hold for 2,4-dinitrophenol (names searched: 2,4-dinitrophenol, 2,4 dinitrophenol, 2,4‐dinitrophenol). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
6 experiments recorded, by species: Mus musculus 3, Drosophila melanogaster 2, Saccharomyces cerevisiae 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 3 ppm food | 6 months | until death | Female | -4 | NS | 0 | NS | PMID 38753230 |
| Mus musculus | UM-HET3 | 3 ppm food | 6 months | until death | Male | 4 | NS | -1 | NS | PMID 38753230 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Oregon-R | 0.1 % wt/vol | Male | 12 | S | NA | PMID 6821144 | |||
| Drosophila melanogaster | Oregon R | 0.008 | Unknown | 20.2 | NA | 0 | NA | PMID 16266268 | ||
| Mus musculus | Swiss Webster | 1 ppm water | 4 months | until death | Female | 7 | S | NA | PMID 18505478 | |
| Saccharomyces cerevisiae | W303-1A | 10 nM | Unknown | 14.71 | S | NA | PMID 15383542 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="2,4-dinitrophenol") in dog-geroscience-mcp.