Mycophenolic acid in dogs: the evidence
What the aging-research databases and the canine literature hold for Mycophenolic acid (names searched: Mycophenolic acid, Mycophenolic-acid). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
7 experiments recorded, by species: Caenorhabditis elegans 2, Mus musculus 2, Saccharomyces cerevisiae 2, Drosophila melanogaster 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 6.7 ppm food | 9 months | until death | Female | -1 | S | -4 | NS | PMID 38041783 |
| Mus musculus | UM-HET3 | 6.7 ppm food | 9 months | until death | Male | 1 | NS | 5 | NS | PMID 38041783 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 0.82 | NS | NA | PMID 33008901 | |||
| Caenorhabditis elegans | N2 | 10 µM | Unknown | 0.24 | NS | NA | PMID 33008901 | |||
| Drosophila melanogaster | Canton-S | 200 μM | Male | 6.08 | NS | NA | PMID 33008901 | |||
| Saccharomyces cerevisiae | BY4741 | 10 μM | Unknown | 20 | S | NA | PMID 29186697 | |||
| Saccharomyces cerevisiae | BY4742 | 10 µM | Unknown | 22.22 | S | NA | PMID 32232569 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
2 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Mycophenolic acid") in dog-geroscience-mcp.