Enalapril in dogs: the evidence
What the aging-research databases and the canine literature hold for Enalapril (names searched: Enalapril). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
3 experiments recorded, by species: Mus musculus 2, Rattus norvegicus 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 120 ppm food (20 ppm/day bodyweight) | 4 months | until death | Female | 0 | NS | 0 | NS | PMID 19587680 |
| Mus musculus | UM-HET3 | 120 ppm food (20 ppm/day bodyweight) | 4 months | until death | Male | 0 | NS | 0 | NS | PMID 19587680 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Rattus norvegicus | Wistar | 10 mg/kg/day | Male | 21.36 | S | NA | PMID 17557916 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
| Species | Reported dose | mg/kg | Km factor | Dog-equivalent mg/kg | ITP | Source |
|---|---|---|---|---|---|---|
| Rattus norvegicus | 10 mg/kg/day | 10.0 | 0.3 | 3.0 | No | PMID 17557916 |
Canine aging literature (Europe PMC corpus)
1 corpus records mention this compound.
Records matching randomized or placebo-controlled trial vocabulary
- Effects of enalapril on exercise tolerance and longevity in dogs with heart failure produced by iatrogenic mitral regurgitation. (Journal of veterinary internal medicine, 1996). PMID 8683486
…One dog in each replicate received placebo, and the other received 0.5 mg/kg of enalapril sid for 9 days and bid thereafter…
Top hits in the core tier
- Effects of enalapril on exercise tolerance and longevity in dogs with heart failure produced by iatrogenic mitral regurgitation. (Journal of veterinary internal medicine, 1996). PMID 8683486
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Enalapril") in dog-geroscience-mcp.