Alpha-ketoglutarate in dogs: the evidence
What the aging-research databases and the canine literature hold for Alpha-ketoglutarate (names searched: Alpha-ketoglutarate, Alpha ketoglutarate, Alpha‐ketoglutarate). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
18 experiments recorded, by species: Caenorhabditis elegans 7, Mus musculus 6, Caenorhabditis briggsae 3, Drosophila melanogaster 2.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 20000 ppm food | 18 months | until death | Female | 1 | NS | -5 | NS | PMID 38753230 |
| Mus musculus | UM-HET3 | 20000 ppm food | 18 months | until death | Male | 3 | NS | -3 | NS | PMID 38753230 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis briggsae | AF16 | 8 mM | Unknown | 7.69 | NS | NA | PMID 31820364 | |||
| Caenorhabditis briggsae | HK104 | 8 mM | Unknown | -7.89 | NS | NA | PMID 31820364 | |||
| Caenorhabditis briggsae | JU1348 | 8 mM | Unknown | -3.85 | NS | NA | PMID 31820364 | |||
| Caenorhabditis elegans | N2 | 8 mM | Unknown | 29.4 | S | NA | PMID 24828042 | |||
| Caenorhabditis elegans | N2 | 1 mM | Unknown | 15 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 5 mM | Unknown | 11 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 10 mM | Unknown | 7 | NS | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 10 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | 8 mM | Unknown | 47.9 | S | NA | PMID 26190651 | ||||
| Caenorhabditis elegans | MY16 | 8 mM | Unknown | 56.25 | S | NA | PMID 31820364 | |||
| Drosophila melanogaster | WDah | 5 µM | Female | 8.54 | S | NA | PMID 31242135 | |||
| Drosophila melanogaster | Canton-S | 20 μM | Female | 7.74 | S | NA | PMID 33008901 | |||
| Mus musculus | C57BL/6J | 20000 ppm food | 18 months | until death | Female | 3 | S | 3 | S | PMID 32877690 |
| Mus musculus | C57BL/6J | 20000 ppm food | 18 months | until death | Female | 6 | S | 9 | S | PMID 32877690 |
| Mus musculus | C57BL/6J | 20000 ppm food | 18 months | until death | Male | 4 | NS | 2 | NS | PMID 32877690 |
| Mus musculus | C57BL/6J | 20000 ppm food | 18 months | until death | Male | 4 | NS | 8 | NS | PMID 32877690 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
1 corpus records mention this compound.
Top hits in the core tier
- Effect of hypoxia, aging and pharmacological treatment on muscular metabolites and enzyme activities. (Il Farmaco; edizione scientifica, 1988). PMID 3224709
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Alpha-ketoglutarate") in dog-geroscience-mcp.