4-phenylbutyrate in dogs: the evidence
What the aging-research databases and the canine literature hold for 4-phenylbutyrate (names searched: 4-phenylbutyrate, 4 phenylbutyrate, 4‐phenylbutyrate). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
3 experiments recorded, by species: Mus musculus 2, Drosophila melanogaster 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 1000 ppm food | 9 months | until death | Female | -2 | S | -6 | NS | PMID 38041783 |
| Mus musculus | UM-HET3 | 1000 ppm food | 9 months | until death | Male | 3 | NS | 3 | NS | PMID 38041783 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Canton S | 5 mM | Unknown | 40 | NA | 41 | NA | PMID 11792861 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="4-phenylbutyrate") in dog-geroscience-mcp.