Leucine in dogs: the evidence
What the aging-research databases and the canine literature hold for Leucine (names searched: Leucine). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
10 experiments recorded, by species: Caenorhabditis elegans 8, Mus musculus 2.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 40000 ppm food | 5 months | until death | Female | -2 | NS | 5 | NS | PMID 36179270 |
| Mus musculus | UM-HET3 | 40000 ppm food | 5 months | until death | Male | 0 | NS | -1 | NS | PMID 36179270 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 10 mM | Unknown | 3 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 5 mM | Unknown | 3 | NS | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 1 mM | Unknown | 3 | NS | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 5 mM | Unknown | 9.5 | S | 6.45 | NA | PMID 26620638 | ||
| Caenorhabditis elegans | N2 | 10 mM | Unknown | 7 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 5 mM | Unknown | 6 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 1 mM | Unknown | 16 | S | NA | PMID 25643626 | |||
| Caenorhabditis elegans | N2 | 5 mM | Unknown | 6.84 | S | 7.32 | NA | PMID 26620638 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
11 corpus records mention this compound.
Records matching randomized or placebo-controlled trial vocabulary
- Comparison of the precursor, amino acid oxidation, and end-product methods for the evaluation of protein turnover in senior dogs. (PloS one, 2024). PMID 38900837
…a specifically designed mask. The volume of CO2 was determined using respirometry. The study included four methods viz. 13C-Leucine, 13C-Phenylalanine evaluated with… - Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. (The American journal of clinical nutrition, 2008). PMID 18842785
…Protein synthesis was assessed with a primed, continuous (14)Cleucine infusion.<h4>Results</h4>Net hepatic glucose uptake in the PoAA condition was…
Top hits in the core tier
- Three new genes associated with longevity in the European Bison. (Veterinary and animal science, 2022). PMID 35957660
- Retinal pigment epithelial dystrophy in Briard dogs. (Research in veterinary science, 1996). PMID 8745249
- Comparative Serum Proteome Profiling of Canine Benign Prostatic Hyperplasia before and after Castration. (Animals : an open access journal from MDPI, 2023). PMID 38136890
- Metabolic phenotype modulation by caloric restriction in a lifelong dog study. (Journal of proteome research, 2013). PMID 23713866
- The Arabidopsis DELAY OF GERMINATION 1 gene affects ABSCISIC ACID INSENSITIVE 5 (ABI5) expression and genetically interacts with ABI3 during Arabidopsis seed development. (The Plant journal : for cell and molecular biology, 2016). PMID 26729600
- EPMA-World Congress 2015 : Bonn, Germany. 3-5 September 2015 (The EPMA Journal, 2016).
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Leucine") in dog-geroscience-mcp.