Nordihydroguaiaretic acid in dogs: the evidence

What the aging-research databases and the canine literature hold for Nordihydroguaiaretic acid (names searched: Nordihydroguaiaretic acid, NDGA, masoprocol, Nordihydroguaiaretic-acid). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.

Lifespan experiments in other species (DrugAge)

22 experiments recorded, by species: Mus musculus 11, Aedes aegypti 5, Caenorhabditis elegans 3, Drosophila melanogaster 3.

NIA Interventions Testing Program rows

Species	Strain	Dose	Age at start	Duration	Sex	Mean lifespan Δ%	Mean sig.	Max lifespan Δ%	Max sig.	Source
Mus musculus	UM-HET3	2500 ppm food (417 ppm bodyweight)	9 months	until death	Male	12	S	0	NS	PMID 18631321
Mus musculus	UM-HET3	2500 ppm food (417 ppm bodyweight)	9 months	until death	Female	0	NS	0	NS	PMID 18631321
Mus musculus	UM-HET3	5000 ppm food	6 months	until death	Female	-3	NS	-3	NS	PMID 27312235
Mus musculus	UM-HET3	5000 ppm food	6 months	until death	Male	9	S	2	NS	PMID 27312235
Mus musculus	UM-HET3	2500 ppm food	6 months	until death	Male	10	S	0	NS	PMID 27312235
Mus musculus	UM-HET3	800 ppm food	6 months	until death	Male	6	S	2	NS	PMID 27312235

Other DrugAge rows (sample)

Species	Strain	Dose	Age at start	Duration	Sex	Mean lifespan Δ%	Mean sig.	Max lifespan Δ%	Max sig.	Source
Aedes aegypti		0.001% (w/v)			Male	11.9	NS		NA	PMID 3749035
Aedes aegypti		0.005% (w/v)			Male	64.3	S		NA	PMID 3749035
Aedes aegypti		0.01% (w/v)			Female	13.6	NS		NA	PMID 3749035
Aedes aegypti		0.005% (w/v)			Female	6.7	NS		NA	PMID 3749035
Aedes aegypti		0.001% (w/v)			Female	42.7	S		NA	PMID 3749035
Caenorhabditis elegans	N2	100 µM			Unknown	21.4	S		NA	PMID 31602311
Caenorhabditis elegans	N2	10 µM			Unknown	-21.33	S		NA	PMID 33008901
Caenorhabditis elegans	N2	100 µM			Unknown	-16.08	S		NA	PMID 33008901
Drosophila melanogaster	Oregon-R	0.5 % wt/vol			Male	12	NS		NA	PMID 6821144
Drosophila melanogaster	Oregon-R-C	1 mg/ml			Unknown		NS		NA	PMID 25380600
Drosophila melanogaster	Oregon-R-C	3 mg/ml			Unknown	23	S		NA	PMID 25380600
Mus musculus	UM-HET3	2500 ppm food (417 ppm bodyweight)	16-18 months	until death	Female	0	NS	0	NS	PMID 20819793
Mus musculus	B6C3F1	4500 ppm food (4.77 ppm/day bodyweight)	12 months	until death	Male	0	NS	0	NS	PMID 25380600
Mus musculus	B6C3F1	3500 ppm food (3.71 ppm/day bodyweight)	12 months	until death	Male	12	S	0	NS	PMID 25380600
Mus musculus	B6C3F1	2500 ppm food (2.65 ppm/day bodyweight)	12 months	until death	Male	0	NS	0	NS	PMID 25380600
Mus musculus	B6C3F1	1500 ppm food (1.59 ppm/day bodyweight)	12 months	until death	Male	0	NS	0	NS	PMID 25380600

Lifespan experiments in dogs (DrugAge)

DrugAge records no dog lifespan experiment for this compound.

Dog-equivalent doses (allometric starting points, not recommendations)

Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.

No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).

Canine aging literature (Europe PMC corpus)

0 corpus records mention this compound.

FDA CVM FOI summaries for dog products

No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).

Evidence gaps reported by the dossier tool

DrugAge has no dog lifespan experiment for this compound.
No record in the canine aging corpus mentions this compound.
No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
No FDA FOI summary for a dog product containing this ingredient.

Reproduce: intervention_dossier(compound="Nordihydroguaiaretic acid") in dog-geroscience-mcp.