TM5441 (PAI-1 inhibitor) in dogs: the evidence
What the aging-research databases and the canine literature hold for TM5441 (PAI-1 inhibitor) (names searched: TM5441 (PAI-1 inhibitor), TM5441 (PAI 1 inhibitor), TM5441-(PAI-1-inhibitor), TM5441 (PAI‐1 inhibitor)). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
2 experiments recorded, by species: Mus musculus 2.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 60 ppm food | 11 months | until death | Female | 0 | NS | -1 | NS | PMID 30916479 |
| Mus musculus | UM-HET3 | 60 ppm food | 11 months | until death | Male | -4 | NS | 2 | NS | PMID 30916479 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="TM5441 (PAI-1 inhibitor)") in dog-geroscience-mcp.