Canagliflozin in dogs: the evidence
What the aging-research databases and the canine literature hold for Canagliflozin (names searched: Canagliflozin). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
6 experiments recorded, by species: Mus musculus 6.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 180 ppm food (30 ppm bodyweight) | 7 months | until death | Female | 1 | NS | 1 | NS | PMID 32990681 |
| Mus musculus | UM-HET3 | 180 ppm food (30 ppm bodyweight) | 7 months | until death | Male | 14 | S | 9 | S | PMID 32990681 |
| Mus musculus | UM-HET3 | 180 ppm food | 6 months | until death | Female | -1 | NS | 4 | NS | PMID 38753230 |
| Mus musculus | UM-HET3 | 180 ppm food | 6 months | until death | Male | 9 | S | 5 | NS | PMID 38753230 |
| Mus musculus | UM-HET3 | 180 ppm food | 16 months | until death | Female | -6 | S | -8 | NS | PMID 38753230 |
| Mus musculus | UM-HET3 | 180 ppm food | 16 months | until death | Male | 14 | S | 4 | S | PMID 38753230 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
2 corpus records mention this compound.
Top hits in the core tier
- Sex-dimorphic immune trajectories across the canine lifespan and early-life signatures of geroprotective interventions (, 2026). doi:10.64898/2026.09.09.750505
- Newer antidiabetic drugs and calorie restriction mimicry. (Indian journal of endocrinology and metabolism, 2016). PMID 26904485
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Canagliflozin") in dog-geroscience-mcp.