Aspirin in dogs: the evidence
What the aging-research databases and the canine literature hold for Aspirin (names searched: Aspirin, acetylsalicylic acid, acetylsalicylic-acid). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
33 experiments recorded, by species: Drosophila melanogaster 13, Mus musculus 10, Acheta domesticus 6, Caenorhabditis elegans 4.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 21 ppm food (3.3 ppm bodyweight) | 4 months | until death | Female | 0 | NS | 0 | NS | PMID 18631321 |
| Mus musculus | UM-HET3 | 21 ppm food (3.3 ppm bodyweight) | 4 months | until death | Male | 8 | S | 0 | NS | PMID 18631321 |
| Mus musculus | UM-HET3 | 200 ppm food | 11 months | until death | Female | 1 | NS | 1 | NS | PMID 30916479 |
| Mus musculus | UM-HET3 | 200 ppm food | 11 months | until death | Male | 1 | NS | 2 | NS | PMID 30916479 |
| Mus musculus | UM-HET3 | 60 ppm food | 11 months | until death | Female | 1 | NS | -1 | NS | PMID 30916479 |
| Mus musculus | UM-HET3 | 60 ppm food | 11 months | until death | Male | -1 | NS | 3 | NS | PMID 30916479 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Canton S | 490 mg/100 mL of medium | Female | 12 | NS | 43 | NA | PMID 4397875 | ||
| Drosophila melanogaster | Canton S | 490 mg/100 mL of medium | Male | 31 | S | 18 | NA | PMID 4397875 | ||
| Acheta domesticus | 2.263x10^4 g aspirin/g food | Unknown | 111 | S | NA | PMID 25833406 | ||||
| Acheta domesticus | 5.65x10^5 g aspirin/g food | Unknown | 134 | S | NA | PMID 25833406 | ||||
| Acheta domesticus | 5.65x10^5 g aspirin/g food | Female | 52 | S | NA | PMID 25833406 | ||||
| Acheta domesticus | 2.263x10^4 g aspirin/g food | Male | 77 | S | NA | PMID 25833406 | ||||
| Acheta domesticus | 5.65x10^5 g aspirin/g food | Male | 67 | S | NA | PMID 25833406 | ||||
| Acheta domesticus | 2.263x10^4 g aspirin/g food | Female | 49 | S | NA | PMID 25833406 | ||||
| Caenorhabditis elegans | N2 | 1 µM | Unknown | 20.9 | S | NA | PMID 22866967 | |||
| Caenorhabditis elegans | N2 | 0.5 µM | Unknown | 23 | S | NA | PMID 22866967 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 16 | S | NA | PMID 23485446 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 14.24 | S | NA | PMID 28910305 | |||
| Drosophila melanogaster | Oregon-R | 2.5 mg/mL | Male | -16.06 | S | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 0.5 mg/mL | Male | -9.04 | S | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 0.25 mg/mL | Male | -1.58 | NS | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 2.5 mg/mL | Male | -2.19 | NS | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 0.5 mg/mL | Male | 0.48 | NS | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 0.001 M | Male | 0.62 | NS | NA | PMID 3921599 | |||
| Drosophila melanogaster | Oregon-R | 0.015 M | Male | -7.12 | S | NA | PMID 3921599 | |||
| Drosophila melanogaster | cross between Canton S females with Oregon RC males | 20 mg/100 mL of medium | Female | -14 | NS | 5 | NA | PMID 4397875 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
2 corpus records mention this compound.
Records matching randomized or placebo-controlled trial vocabulary
- The treatment of rejection. A trial of acetylsalicylic acid, dipyridamole, and heparin. (Transplantation, 1975). PMID 1099729
…Treatment with acetylsalicylic acid, dipyridamole, and heparin failed to improve the selective platelet destruction which occurred in untreated animals, and it did not improve…
Top hits in the core tier
- The treatment of rejection. A trial of acetylsalicylic acid, dipyridamole, and heparin. (Transplantation, 1975). PMID 1099729
- Comparison of enoxaparin, hirulog, and heparin as adjunctive antithrombotic therapy during thrombolysis with rtPA in the stenosed canine coronary artery. (Thrombosis and haemostasis, 1997). PMID 9364998
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Aspirin") in dog-geroscience-mcp.