Beta-guanidinopropionic acid in dogs: the evidence
What the aging-research databases and the canine literature hold for Beta-guanidinopropionic acid (names searched: Beta-guanidinopropionic acid, Beta guanidinopropionic acid, Beta-guanidinopropionic-acid, Beta‐guanidinopropionic acid). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
7 experiments recorded, by species: Drosophila melanogaster 4, Mus musculus 2, Caenorhabditis briggsae 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 3300 ppm food | 6 months | unti death | Female | -1 | NS | 2 | NS | PMID 33145977 |
| Mus musculus | UM-HET3 | 3300 ppm food | 6 months | unti death | Male | -1 | NS | 0 | NS | PMID 33145977 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis briggsae | AF16 | 300 mM | Unknown | -16.82 | S | NA | PMID 31998863 | |||
| Drosophila melanogaster | w1118 | 900 mM | Female | 13.3 | S | NA | PMID 26120775 | |||
| Drosophila melanogaster | w1118 | 900 mM | Male | 9.1 | S | NA | PMID 26120775 | |||
| Drosophila melanogaster | w1118 | 900 mM | Female | -63 | S | NA | PMID 34141906 | |||
| Drosophila melanogaster | w1118 | 900 mM | Male | -54 | S | NA | PMID 34141906 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Beta-guanidinopropionic acid") in dog-geroscience-mcp.