Resveratrol in dogs: the evidence
What the aging-research databases and the canine literature hold for Resveratrol (names searched: Resveratrol). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
173 experiments recorded, by species: Drosophila melanogaster 76, Caenorhabditis elegans 34, Anastrepha ludens 24, Saccharomyces cerevisiae 15, Mus musculus 6, Nothobranchius guentheri 5, Daphnia pulex 4, Anopheles stephensi 3, Aedes aegypti 2, Caenorhabditis briggsae 2, Apis mellifera 1, Nothobranchius furzeri 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 1200 ppm food (200 ppm/day bodyweight) | 12 months | until death | Female | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 1200 ppm food (200 ppm/day bodyweight) | 12 months | until death | Male | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 300 ppm food (50 ppm/day bodyweight) | 12 months | until death | Female | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 300 ppm food (50 ppm/day bodyweight) | 12 months | until death | Male | 0 | NS | 0 | NS | PMID 20974732 |
| Mus musculus | UM-HET3 | 300 ppm food | 4 months | until death | Female | 5 | NS | 0 | NS | PMID 22451473 |
| Mus musculus | UM-HET3 | 300 ppm food | 4 months | until death | Male | 3 | NS | 0 | NS | PMID 22451473 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 1 mM | Unknown | 31.1 | S | NA | PMID 27190265 | |||
| Caenorhabditis elegans | N2 | 500 µM | Unknown | 17.8 | S | NA | PMID 27190265 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 7.4 | S | NA | PMID 27190265 | |||
| Aedes aegypti | Liverpool | 100 µM | Female | 49.6 | S | -2.04 | NA | PMID 27732590 | ||
| Aedes aegypti | Liverpool | 100 μM | Male | 52.99 | S | 3.4 | NA | PMID 27732590 | ||
| Anastrepha ludens | 100 µM | Female | -5.6 | NS | 10.2 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | -2.3 | NS | 26.5 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 15.6 | S | 22.5 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 6.2 | NS | 7.3 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 2.6 | NS | 13.9 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | -4.9 | NS | 5.4 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 8 | NS | 36.3 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 11.2 | NS | -1.4 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 3.8 | NS | 5.7 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 2.5 | NS | -7.7 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 1.5 | NS | 10 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 2.6 | NS | 17.5 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 2.3 | NS | 5 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Male | 1.3 | NS | 16.6 | NA | PMID 19264118 | |||
| Anastrepha ludens | 100 µM | Female | 0 | NS | -3.4 | NA | PMID 19264118 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
3 corpus records mention this compound.
Top hits in the core tier
- Pleiotropic Effects of Resveratrol on Aging-Related Cardiovascular Diseases-What Can We Learn from Research in Dogs? (Cells, 2024). PMID 39451250
- Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age. (GeroScience, 2021). PMID 33733399
- Dietary activators of Sirt1. (Molecular and cellular endocrinology, 2009). PMID 19010386
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Resveratrol") in dog-geroscience-mcp.