Fisetin in dogs: the evidence
What the aging-research databases and the canine literature hold for Fisetin (names searched: Fisetin). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
7 experiments recorded, by species: Mus musculus 5, Drosophila melanogaster 1, Saccharomyces cerevisiae 1.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 600 ppm food fed on a repeated cycle of 3 days on and 11 days off | 20 months | until death | Female | -1 | NS | 2 | NS | PMID 38041783 |
| Mus musculus | UM-HET3 | 600 ppm food fed on a repeated cycle of 3 days on and 11 days off | 20 months | until death | Male | 7 | NS | -1 | NS | PMID 38041783 |
| Mus musculus | UM-HET3 | 600 ppm food fed continuously | 20 months | until death | Female | 1 | NS | -1 | NS | PMID 38041783 |
| Mus musculus | UM-HET3 | 600 ppm food fed continuously | 20 months | until death | Male | -5 | NS | 0 | NS | PMID 38041783 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Canton S | 100 µm | Unknown | 23 | S | NA | PMID 15254550 | |||
| Mus musculus | f1 C57BL/6:FVB | 500 ppm food | 21 months | until death | Pooled | 10 | S | 6 | NA | PMID 30279143 |
| Saccharomyces cerevisiae | PSY316AT MATα | 10 µM | Unknown | 55 | S | NA | PMID 12939617 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Fisetin") in dog-geroscience-mcp.