Minocycline in dogs: the evidence
What the aging-research databases and the canine literature hold for Minocycline (names searched: Minocycline). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
29 experiments recorded, by species: Caenorhabditis elegans 15, Drosophila melanogaster 12, Mus musculus 2.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 300 ppm food | 6 months | unti death | Female | -3 | NS | 0 | NS | PMID 33145977 |
| Mus musculus | UM-HET3 | 300 ppm food | 6 months | unti death | Male | 5 | NS | -2 | NS | PMID 33145977 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 200 µM | Unknown | 30 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 48 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 50 µM | Unknown | 33 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 200 µM | Unknown | 14 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 30 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 200 µM | Unknown | 10 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 51 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 50 µM | Unknown | 43 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 200 µM | Unknown | 12 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 33 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 50 µM | Unknown | 6 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 200 µM | Unknown | 43 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 36 | S | NA | PMID 30479271 | |||
| Caenorhabditis elegans | N2 | 50 µM | Unknown | 5 | NS | NA | PMID 30479271 | |||
| Drosophila melanogaster | Oregon | 0.05 mM | Male | 49 | S | NA | PMID 22330257 | |||
| Drosophila melanogaster | Oregon R | 0.87 mM | Unknown | 50 | S | 66 | NA | PMID 23185716 | ||
| Drosophila melanogaster | Oregon R | 0.87 mM | Unknown | 50 | S | 25 | NA | PMID 23185716 | ||
| Drosophila melanogaster | Oregon | 0.05 mM | Male | 63 | NA | NA | PMID 23947005 | |||
| Drosophila melanogaster | w1118 | 0.36mM | Female | 15.6 | S | NA | PMID 29152127 | |||
| Drosophila melanogaster | w1118 | 0.05mM | Female | 22.9 | S | NA | PMID 29152127 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
0 corpus records mention this compound.
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- No record in the canine aging corpus mentions this compound.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Minocycline") in dog-geroscience-mcp.