Curcumin in dogs: the evidence
What the aging-research databases and the canine literature hold for Curcumin (names searched: Curcumin). Compiled from DrugAge, the canine aging corpus and FDA CVM FOI summaries; nothing here is inferred.
Lifespan experiments in other species (DrugAge)
42 experiments recorded, by species: Drosophila melanogaster 34, Caenorhabditis elegans 4, Mus musculus 4.
NIA Interventions Testing Program rows
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | UM-HET3 | 2000 ppm food | 4 months | until death | Female | 5 | NS | 0 | NS | PMID 22451473 |
| Mus musculus | UM-HET3 | 2000 ppm food | 4 months | until death | Male | 3 | NS | 0 | NS | PMID 22451473 |
Other DrugAge rows (sample)
| Species | Strain | Dose | Age at start | Duration | Sex | Mean lifespan Δ% | Mean sig. | Max lifespan Δ% | Max sig. | Source |
|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | N2 | 20 µM | Unknown | 39 | S | NA | PMID 21855561 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | 22.5 | S | NA | PMID 25959406 | |||
| Caenorhabditis elegans | N2 | 100 µM | Unknown | -4.89 | S | NA | PMID 33008901 | |||
| Caenorhabditis elegans | N2 | 10 µM | Unknown | -7.11 | S | NA | PMID 33008901 | |||
| Drosophila melanogaster | Ives | 250 µM | Male | 18 | S | NA | PMID 20645870 | |||
| Drosophila melanogaster | Canton S | 100 µM | Female | 19 | S | NA | PMID 20645870 | |||
| Drosophila melanogaster | Oregon R | 0.5 mg/g | Female | 15.5 | S | -1.9 | NA | PMID 22653297 | ||
| Drosophila melanogaster | Oregon R | 0.5 mg/g | Male | 6.2 | NS | -5.2 | NA | PMID 22653297 | ||
| Drosophila melanogaster | Oregon R | 1 mg/g | Male | 25.8 | S | -5.2 | NA | PMID 22653297 | ||
| Drosophila melanogaster | Oregon R | 1 mg/g | Female | 12.6 | S | 13 | NA | PMID 22653297 | ||
| Drosophila melanogaster | Ra | 100 mM | Female | 46.8 | S | 38 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 200 mM | Unknown | S | NA | PMID 23063786 | ||||
| Drosophila melanogaster | Ra | 10 mM | Unknown | NS | NA | PMID 23063786 | ||||
| Drosophila melanogaster | Ra | 100 mM | Male | 16.3 | S | 25 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Male | 49 | S | 49 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Female | 25.5 | S | 0 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Male | -8.2 | S | 25 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Female | -17 | S | 3 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Unknown | 25 | S | 20.2 | NA | PMID 23063786 | ||
| Drosophila melanogaster | Ra | 100 mM | Male | -10.2 | NS | NA | PMID 23063786 |
Lifespan experiments in dogs (DrugAge)
DrugAge records no dog lifespan experiment for this compound.
Dog-equivalent doses (allometric starting points, not recommendations)
Method: FDA 2005 Km body-surface-area conversion; starting-point heuristic only.
No mg/kg dose in DrugAge to translate (doses reported as ppm of diet or a concentration).
Canine aging literature (Europe PMC corpus)
2 corpus records mention this compound.
Top hits in the core tier
- Efficacy of TurmiZn, a Metallic Complex of Curcuminoids-Tetrahydrocurcumin and Zinc on Bioavailability, Antioxidant, and Cytokine Modulation Capability. (Molecules (Basel, Switzerland), 2023). PMID 36838654
- Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway. (International journal of molecular sciences, 2021). PMID 34768788
FDA CVM FOI summaries for dog products
No FDA FOI summary for a dog product contains this ingredient (it is not a marketed veterinary product).
Evidence gaps reported by the dossier tool
- DrugAge has no dog lifespan experiment for this compound.
- Corpus mentions exist but no randomized/placebo-controlled dog trial surfaced for it.
- No mg/kg animal dose in DrugAge to translate (doses reported as ppm or % of diet).
- No FDA FOI summary for a dog product containing this ingredient.
Reproduce: intervention_dossier(compound="Curcumin") in dog-geroscience-mcp.