Golden Retriever Lifetime Study (Morris Animal Foundation)
The Golden Retriever Lifetime Study is a prospective cohort of 3,044 US Golden Retrievers enrolled between 2012 and 2015 at 6 months to 2 years of age, followed for life with annual owner and veterinarian questionnaires, examinations and biobanked samples. Its primary outcomes are four cancers; secondary outcomes include other cancers and common age-related diseases. Questionnaire data are available to approved researchers under a data use agreement.
Record
| Design | longitudinal cohort |
|---|---|
| Status | ongoing |
| Setting | client owned |
| Intervention class | none |
| Duration | lifetime follow-up; baseline enrolment June 2012 to April 2015 |
| Dogs | 3,044 |
| Population note | completed baseline enrolment; as of 31 May 2021, 2,251 engaged, 352 died, 441 lost to follow-up |
| Breed | Golden Retriever |
| Age | 6 months to 2 years at enrolment |
| Other | United States |
| Primary outcome | incidence of hemangiosarcoma, lymphoma, osteosarcoma and high-grade mast cell tumors; secondary outcomes include other cancers, hypothyroidism, epilepsy, atopy, otitis externa, hip dysplasia, heart failure and renal failure |
| Lead organisation | Morris Animal Foundation |
| Sponsor or funder | Morris Animal Foundation |
| Start year | 2012 |
| Tags | cohort, golden-retriever, cancer, biobank, lifetime |
Notes: A cancer-focused lifetime cohort rather than an aging study by design, but the only breed-wide lifetime cohort with biobanking in dogs; included as an aging cohort resource.
Sources and verbatim quotes
Cohort profile: The Golden Retriever Lifetime Study (GRLS). (2022) PMID 35679242 (design)
a prospective cohort study investigating nutritional, environmental, lifestyle, and genetic risk factors for cancer and other common diseases in dogs.
Primary outcomes of interest include hemangiosarcoma, lymphoma, osteosarcoma, and high-grade mast cell tumors.
A total of 3,044 United States Golden Retrievers aged 6 months to 2 years completed baseline enrollment from June 2012 to April 2015.
As of May 31, 2021, 2,251 dogs remain engaged in the study, 352 have died, and 441 are lost to follow-up.
Extensive annual questionnaires completed by owners and veterinarians gather information about lifestyle, environmental exposures, physical activity, reproductive history, behavior, diet, medications, and diagnoses.
Questionnaire data are freely available to researchers with approved credentials who agree to a data use agreement.
Reproduce: canine_trial_search(trial_id="golden-retriever-lifetime-study") in dog-geroscience-mcp; dataset canine-trial-registry.