Nutraceutical supplement (phosphatidylserine, Ginkgo biloba, vitamin E, pyridoxine) for short-term memory in aged beagles
Nine aged beagles were tested on a delayed-non-matching-to-position task of short-term visuospatial memory, then given a commercial nutraceutical containing phosphatidylserine, Ginkgo biloba, vitamin E and pyridoxine or a control substance in a two-phase crossover design. Performance accuracy was significantly improved in supplemented dogs compared with controls, and the effect was long lasting. Dose and phase duration are not given in the abstract.
Record
| Design | crossover trial |
|---|---|
| Status | completed |
| Intervention | Commercially available nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine |
| Intervention class | diet or supplement |
| Comparator | Control substance |
| Dogs | 9 |
| Population note | 9 aged beagles tested; split into two groups for the crossover phases |
| Breed | Beagle |
| Age | aged |
| Primary outcome | Performance accuracy on a delayed-non-matching-to-position task (short-term visuospatial memory) |
| Result (as reported) | Performance accuracy was significantly improved in supplemented dogs compared with control dogs and the effect was long lasting. |
| Tags | cognition, nutraceutical, beagle, memory, crossover |
Notes: Dose, phase duration, setting and funding are not stated in the abstract.
Sources and verbatim quotes
Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. (2008) PMID 18481547 (results)
The purpose of the present study was to examine if a commercially available nutraceutical supplement that may be neuroprotective and contains phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine could improve cognitive function in aged beagles.
Nine aged beagles were tested on performance on a delayed-non-matching-to-position task, which is a neuropsychological test of short-term visuospatial memory.
All subjects were tested on 5 baseline sessions; then, to assess the supplement, a crossover design was used in which 1 group received the supplement and the other a control substance in the 1st phase, with treatment conditions being reversed in the 2nd phase.
Performance accuracy was significantly improved in supplemented dogs compared with control dogs and the effect was long lasting.
Reproduce: canine_trial_search(trial_id="beagle-phosphatidylserine-ginkgo-nutraceutical-crossover-2008") in dog-geroscience-mcp; dataset canine-trial-registry.