Prior experience, antioxidants and mitochondrial cofactors in aged beagles (landmark discrimination)
This study fed aged dogs food providing higher levels of vitamin E and tested them on landmark-discrimination tasks. Higher dietary vitamin E produced higher serum vitamin E concentrations and improved landmark-discrimination performance, although factors other than vitamin E also contributed to the response. The published abstract gives no sample size, dose, duration or comparator.
Record
| Design | randomized controlled trial |
|---|---|
| Status | completed |
| Intervention | Food providing higher levels of vitamin E (antioxidants and mitochondrial cofactors) |
| Intervention class | diet or supplement |
| Age | aged dogs |
| Primary outcome | Performance on landmark-discrimination tasks; serum vitamin E concentrations |
| Result (as reported) | providing higher levels of vitamin E in food resulted in higher serum vitamin E concentrations and improved performance on landmark-discrimination tasks in aged dogs. Factors other than vitamin E also contributed to the response but remain undefined. |
| Tags | cognition, antioxidant-diet, vitamin-e, beagle |
Notes: The abstract is a two-sentence summary. Kind is recorded as randomized_controlled_trial from the PubMed publication type (Randomized Controlled Trial; Clinical Trial); the title names prior experience, antioxidants and mitochondrial cofactors in aged beagles, so breed is Beagle by title only. Judged separate from the long-term antioxidant/enrichment longitudinal study because it reports landmark-discrimination and serum vitamin E outcomes not described in that study's reports; merge if other sources show it is the same cohort.
Sources and verbatim quotes
Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles. (2004) PMID 15150725 (results)
Results of this study support the free-radical theory of aging and demonstrated that providing higher levels of vitamin E in food resulted in higher serum vitamin E concentrations and improved performance on landmark-discrimination tasks in aged dogs.
Factors other than vitamin E also contributed to the response but remain undefined.
Reproduce: canine_trial_search(trial_id="beagle-antioxidant-cofactor-landmark-discrimination-2004") in dog-geroscience-mcp; dataset canine-trial-registry.