Canine geroscience evidence

Companion dogs are the one model in which a lifespan intervention can be read out in years rather than decades, in animals that share our environment and our age-related diseases. This site lays out, page by page and with sources, what the aging-research databases, the canine literature and the FDA's veterinary drug reviews actually hold for dogs. It is generated from a database, not written by a model: every figure sits next to the passage it came from.

Sections

• Interventions: for every compound the NIA Interventions Testing Program tested in mice (54) plus veterinary comparators, the dog evidence and the gaps. 0 of 54 have a dog lifespan experiment on record.
• FDA FOI summaries by ingredient: 160 active ingredients, 497 summaries for dog products, as typed records of dose, pharmacokinetics, target-animal safety, effectiveness and adverse reactions with verbatim quotes. The only public, regulator-reviewed source of canine PK and safety-margin data.

Sources and tools

• Canine aging corpus: 3,565 Europe PMC records, dataset.
• FDA CVM FOI summaries for dog products and their structured extraction: dataset.
• HAGR AnAge, DrugAge and GenAge (CC BY 3.0), Dog Aging Project codebooks, Ensembl orthologs, FDA Km dose table: bundled in the server database.
• Agent tools: uvx dog-geroscience-mcp (PyPI), Claude Desktop extension and Claude Code plugin in the repository. The pages name the tool call that reproduces them.
• Machine-readable index for language-model crawlers: llms.txt.